Diagnostic predictive value of ANCA serology
نویسندگان
چکیده
منابع مشابه
Diagnostic value of distinguishing and reporting different perinuclear ANCA (P-ANCA) immunofluorescence patterns: a prospective study.
OBJECTIVES To investigate whether discriminating the classic perinuclear antineutrophil cytoplasmic antibody (P-ANCA) pattern from atypical P-ANCA and uninterpretable patterns improves the diagnostic utility of ANCA testing. METHODS All ANCA requests (n = 3,544) referred to Pathology Queensland were analyzed prospectively over 4 months for P-ANCA pattern subtypes and myeloperoxidase (MPO)-ANC...
متن کاملPredictive value and informational value of diagnostic test results.
If clinical quality assurance and cost-effectiveness of diagnostic testing are to be measured, some sort of measurement of the clinical value of a test result is needed. The predictive value of a test result is not a real measure of its clinical value, and, particularly, when used in the later stages of a diagnostic workup, it can be misleading. Using the same data that go into a calculation of...
متن کاملAutomated interpretation of ANCA patterns - a new approach in the serology of ANCA-associated vasculitis
INTRODUCTION Indirect immunofluorescence (IIF) employing ethanol-fixed neutrophils (ethN) is still the method of choice for assessing antineutrophil cytoplasmic antibodies (ANCA) in ANCA-associated vasculitides (AAV). However, conventional fluorescence microscopy is subjective and prone to high variability. The objective of this study was to evaluate novel pattern recognition algorithms for the...
متن کاملComparative Changes Noted in Renal Biopsies on Light Microscopy of ANCA Positive Vs ANCA Negative Serology.
OBJECTIVES Pauci-immune glomerulonephritis is the commonest cause of rapidly progressive glomerulonephritis (RPGN) which is associated with increased mortality and morbidity. More than 90% of these patients have serological presence of either antineutrophil cytoplasmic antibodies (ANCA), of cytoplamic (C) or perinuclear (P) type. "Immunofluoresence studies" exhibiting minimal or no fluorescence...
متن کاملThe CARI guidelines. ANCA serology in the diagnosis and management of ANCA-associated renal vasculitis.
a. Serum anti-neutrophil cytoplasmic antibody (ANCA) measurement should not be used alone in the initial diagnosis of ANCA-associated vasculitis (AAV) but should be used in combination with the gold standard of tissue diagnosis. (Level 1 evidence) b. Measurement of ANCA by both ELISA and indirect immunofluorescence (IIF) in combination ensures optimal test sensitivity and specificity. (Level I ...
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ژورنال
عنوان ژورنال: Kidney International
سال: 1998
ISSN: 0085-2538
DOI: 10.1038/ki.1998.36